El papel de los Toll Like Receptors (TLRs) en la respuesta inmune innata contra el cáncer cérvico-uterino
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La infección producida por el virus del papiloma humano (VPH) representa un problema de salud importante en la población femenina mexicana. Los papilomavirus humanos oncogénicos (VPHs) representan el agente causal primario del cáncer cervico-uterino y están íntimamente asociados con un subgrupo de cánceres vulvares, anales y peneanos. Aunque se han identificado más de 200 de genotipos diferentes, se han identificado como oncogénicos el VPH tipo-16 (VPH 16) y está presente en más de 90% de los cánceres cervicales, se sabe que está íntimamente asociada con el desarrollo de lesiones precancerígenas denominadas neoplasia intraepitelial cervical (NIC), así como con el cáncer cérvico uterino (CaCu). La respuesta inmune innata contra el VPH es la primera línea de defensa contra el virus, ésta incluye el reconocimiento a través de "receptores del reconocimiento del patrón" (PRR), específicamente los "Toll-like receptos" (TLRs) que inician vías de señalización para inducir la expresión de genes que codifican para moléculas involucradas en la respuesta inflamatoria y en el cambio de clase de las inmunoglobulinas.
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